文献类型：期刊文献

英文题名：One-shot synthesis and solution properties of ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate

作者：Zhang, Yan[1];Xu, Yue[1];Wei, Chao[1];Sun, Chuanhao[1];Yan, Bingkun[1];Hu, Jieni[1];Lu, Wei[2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Fudan Univ, Dept Pharmaceut, Sch Pharm,State Key Lab Mol Engn Polymers, Key Lab Smart Drug Delivery,Minist Educ, Shanghai 200433, Peoples R China

年份：2019

卷号：10

期号：17

起止页码：2143

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20191806864050);WOS:【SCI-EXPANDED(收录号:WOS:000465421800006)】；

基金：This work was partially supported by National Natural Science Foundation of China (51873062, 81673018), Shanghai Natural Science Foundation (17ZR1407100), School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, SDD2017-04) and Ministry of Education and 111 Project (B14018).

语种：英文

外文关键词：Polyethylene glycols - Polyols - Binary alloys - Ethylene glycol - Hydrophilicity - Amines - Oxidation - Polycarbonates

摘要：Herein, we reported a dual-responsive methoxy poly(ethylene glycol)-b-polycarbonate (mPEG-b-poly (MN-co-MSe)) by installing selenide and tertiary amine groups onto the backbone via a one-shot enzyme-catalyzed ring-opening copolymerization. The structure of the copolymers was confirmed by NMR, FTIR and SEC. The amphiphilic copolymers can self-assemble to nanosized micelles, and the micelles had excellent ROS/ pH responsive behavior, which was attributed to the enhanced hydrophilicity by the oxidation of the selenide groups to hydrophilic selenoxide or selenone, as well as the protonation of tertiary amine groups. The oxidation mechanism was clarified by 77Se-NMR, FTIR and TGA data. Thereafter, UV, DLS and TEM techniques were employed to demonstrate the variation of the transmittance, size, and morphology of the micelles. Furthermore, MTT assays showed that the selenide-and amine-containing polycarbonates and the oxidized products were nontoxic up to a tested concentration of 200 mu g mL-1. Therefore, these results proved that the micelles could provide unique dual ROS and pH responsiveness, making them extremely attractive for cancer therapy.