文献类型：期刊文献

英文题名：Kinetic Study of Disulfonimide-Catalyzed Cyanosilylation of Aldehydes by Using a Method of Progress Rates

作者：Zhang, Zhipeng[1,2];Klussmann, Martin[2];List, Benjamin[2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany

年份：2020

卷号：31

期号：16

起止页码：1593

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000570338800009)】；

基金：This work was supported by Shanghai Pujiang Program (18PJ1402200), the National Natural Science Foundation of China (21702059), and the Fundamental Research Funds for the Central Universities (222201814014). We gratefully thank the Max Planck Society, the European Research Council (Advanced Grant 'High Performance Lewis Acid Organocatalysis, HIPOCAT' to B.L.), and the Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science & Technology (JKVJ12001010).

语种：英文

外文关键词：kinetics; progress rates; disulfonimides; cyanation; -organocatalysis; aldehydes

摘要：Kinetic study of organic reactions, especially multistep catalytic reactions, is crucial to in-depth understanding of reaction mechanisms. Here we report our kinetic study on the chiral disulfonimide-catalyzed cyanosilylation of an aldehyde, which revealed that two molecules of TMSCN are involved in the rate-determining C-C bond-forming step. In addition, the apparent activation energy, enthalpy of activation, and entropy of activation were deduced through a study of the temperature dependence of the reaction rates. More importantly, a novel and efficient method that makes use of the progress rates was developed to treat kinetic data obtained by continuous monitoring of the progress of a reaction by in situ FTIR.