文献类型：期刊文献

英文题名：Pd-Catalyzed Site-Selective p-Hydroxyphenyloxylation of Benzylic α-C(sp3)-H Bonds with 1,4-Benzoquinone

作者：Song, Guangjun;Zheng, Ziwei;Wang, Yanhui;Yu, Xinhong[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, State Key Lab Bioengn Reactors, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：18

期号：23

起止页码：6002

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000389396100009)，CCR-EXPANDED(收录号:WOS:000389396100009)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (21476078) and the Science and Technology Commission of Shanghai Municipality (No. 12431900902).

语种：英文

摘要：A Pd-catalyzed, site-selective p-hydroxypheny-loxylation of benzylic alpha-C(sp(3))-H bonds with 1,4-benzoquinone using thioamide as a directing group is reported. 1,4-Benzoquinone is employed as the p-hydroxyphenyloxy source without extra oxidants. This method exclusively gives site selectivity at alpha-C(sp(3))-H bonds rather than the usual beta-C(sp(3))-H bonds through C-H activation mode. The reactions proceed with high functional group tolerance in yields of 42-93%.