文献类型：期刊文献

英文题名：Facile synthesis of manganese silicate nanoparticles for pH/GSH-responsive T1-weighted magnetic resonance imaging

作者：Li, X. W.[1];Zhao, W. R.[1];Liu, Y. J.[2];Liu, X. H.[3];Shi, P.[2];Li, Y. S.[1];Shi, J. L.[1,4]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200032, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2016

卷号：4

期号：24

起止页码：4313

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20162602533131);WOS:【SCI-EXPANDED(收录号:WOS:000378936400009)】；

基金：This study was financially supported by the 973 Program (Grant No. 2012CB933602), the National Natural Science Foundation of China (Grant No. 51572084, 51461165202, 51472085, and 51132009), the Natural Science Foundation of Shanghai (Grant No. 14ZR1410100), the Fundamental Research Funds for the Central Universities (222201313010), and the Nano-Special Foundation for Shanghai Committee of Science and Technology (12nm0502600).

语种：英文

外文关键词：Cost effectiveness - Synthesis (chemical) - Biocompatibility - Cytotoxicity - Silicates - Tissue - Solutions - Diagnosis - Manganese compounds - Nanomagnetics - Nanoparticles

摘要：Contrast agents (CAs) play an important role in enhancing the magnetic resonance imaging (MRI) performance for accurate tumor diagnosis, which, however, may give rise to unexceptional issues such as in vivo accumulation and bio-toxicity. Here we report on manganese silicate nanoparticles (denoted as MnSNs) as highly biocompatible and pH/GSH-responsive T-1-weighted MRI CAs. The MnSNs were synthesized via a facile, cost-effective and environmentally friendly route based on one-step rapid precipitation between the Mn2+ cation and the SiO32- anion in aqueous solution at room temperature without any other additives, and showed excellent dispersion stability in water or PBS for weeks without any surface modification at ambient temperature. The MnSNs present an efficient pH/GSH-responsive T-1-MRI feature based on the rapid changes in the relaxation rate in a mildly acidic/reducing environment both in vitro and in vivo, and furthermore, MnSNs showed negligible cellular cytotoxicity in vitro, no distinct tissue toxicity in vivo and fast clearance from the body organs and tissues in 24-72 h. Thus, the MnSNs are able to serve as a novel class of highly promising T-1-MRI CAs for clinical cancer diagnosis.