文献类型：期刊文献

中文题名：Photo-controllable antifouling hydrogels embedded with AgNPs coated spiropyran functionalized mesoporous silica for long-term antibacterial activity

作者：Wei Su[1,2];Fei Wang[1,2];Bing Chen[2];Ruoke Li[2];Jindian Liu[1,2];Junjie Xu[2];Jianhua Fan[1,2];Yueling Liu[1,2]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]Department of Applied Biology,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China

年份：2024

卷号：17

期号：9

起止页码：8337

中文期刊名：Nano Research

外文期刊名：纳米研究（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(No.21804043);the Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

中文关键词：light-responsive;silver nanoparticles;spiropyran;mesoporous silica nanoparticles;antibacterial activity

摘要：Silver nanoparticles(AgNPs)are widely used in antimicrobial applications.However,its easy aggregation and rapid loss hinder the effective antifouling.To address this issue,a novel stimuli-responsive antibacterial nanocomposite(Ag@SP-MSN)was developed based on spiropyran covalently conjugated mesoporous silica nanoparticles(284.6 nm)and AgNPs(27.1 nm)via strong electrostatic attraction.Both transmission electron microscopy(TEM)and atomic force microscopy(AFM)images proved the successful modification of AgNPs onto SP-MSN.The light-induced maximum loading amount towards AgNPs was calculated to be 95.0 wt.%after ultraviolet irradiation,while the amount of AgNPs released from Ag@SP-MSN was 94.4 wt.%under visible light in the aid of ammonia(0.1%,v/v).Upon cycled light irradiation,Ag@SP-MSN could recover 84.5 wt.%of AgNPs even after four cycles.The proposed Ag@SP-MSN exhibited better antibacterial activity against both E.coli and S.aureus than Ag@MSN under visible light illumination,indicating the efficient photo-responsive isomerization of spiropyran.Furthermore,the Ag@SP-MSN embedded gel demonstrated outstanding antifouling ability even after 21 days when compared to AgNPs gel.The long-term photo-controllable antifouling property proved the excellent reversible absorption and release of Ag@SP-MSN towards AgNPs.This work provides new insights into the safe utilization of nanomaterials,offering promising advancements to meet clinical antibacterial requirements.