文献类型：期刊文献

英文题名：Cis-configuration: A new tactic/rationale for neonicotinoid molecular design

作者：Shao, Xusheng[1]; Lee, Philip W.[1]; Liu, Zewen[2]; Xu, Xiaoyong[1]; Li, Zhong[1]; Qian, Xuhong[1]

机构：[1] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; [2] Key Laboratory of Monitoring and Management of Plant Disease and Insect, Ministry of Agriculture, Nanjing Agricultural University, Tongwei Road 6, Nanjing 210095, China

年份：2011

卷号：59

期号：7

起止页码：2943

外文期刊名：Journal of Agricultural and Food Chemistry

收录：EI(收录号：20111613912826)

语种：英文

外文关键词：Organic compounds

摘要：Resistance development and limited lepidopteran activities call for the discovery of "super-neonicotinoids" solving these problems. Compounds with the cis-configuration offer an opportunity for further optimization. Fixing the nitro group in the cis-configuration provided a new approach for neonicotinoid molecular design. Introductions of the heterocycle or a bulky group are two synthesis concepts to fix the cis-configuration of the nitro group. The design, synthesis, bioactivity, and preliminary modes of action of five types of cis-neonicotinoids are reviewed. cis-and trans-Neonicotinoids have some differences in bioactivities and modes of action. This study focused, especially, on the reaction diversities of nitromethylene analogues of imidacloprid with various aldehydes. ? 2010 American Chemical Society.