文献类型：期刊文献

英文题名：Engineering raloxifene as multi-stimuli-responsive mono-component crystalline RTP emitters with red afterglow for targeted tumor imaging

作者：Gu, Pengli[1];Pan, Zhichao[1];Zhang, Xinyi[1];Mei, Ju[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem,Joint I, Key Lab Adv Mat,Inst Fine Chem,Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2026

卷号：529

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20260319908985);WOS:【SCI-EXPANDED(收录号:WOS:001671101200001)】；

基金：This work was supported by the National Natural Science Foundation of China (22575087, 22275055, 22025503, 22220102004) , Shanghai Science and Technology Commission Basic Project Shanghai Natural Science Foundation (21ZR1417600) , Science and Technology Commission of Shanghai Municipality (24DX1400200) , Programme of Introducing Talents of Discipline to Universities (B16017) , Shanghai Science and Technology Committee (17520750100) , Science and Technology Commission of Shanghai Municipality (21JC1401700) , and the Fundamental Research Funds for the Central Universities. This research was also supported by the "Oriental Talent Program Youth Project" (QNJY2024080) . The authors thank the support of Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. The authors acknowledge Dr. Binbin Chen and Dr. Yating Gao at East China University of Science and Technology for their expert assistance in performing the variable-temperature phosphorescence measurements.

语种：英文

外文关键词：Organic room-temperature phosphorescence; (RTP); Molecular packing; Stimuli-responsiveness; Nanoparticles; Bioimaging

摘要：Organic room-temperature phosphorescence (RTP) materials have garnered widespread attention due to their unique optical properties, yet achieving long-wavelength emission in aqueous solutions remains a significant challenge. Herein, by halogenating the raloxifene-based framework and with the help of crystallization strategy, we construct a series of single-component purely organic RTP materials (i.e., RALO-F, RALO-Cl, and RALO-Br) with tunable emissions, red afterglow, and multi-stimuli responsiveness. In the crystalline phase, the antiparallel dimeric packing structures of the raloxifene analogues enhances the RTP performance via a dual mechanism that improves intersystem crossing (ISC) while suppressing non-radiative decay through hydrogen-bonding networks. Furthermore, red light-emitting RTP nanocrystals RALO-F@F127 NPs, RALO-Cl@F127 NPs, and RALO-Br@F127 NPs that overcome the limitations of traditional visible light-emitting systems have been successfully engineered. The nanocrystals were formulated with an ideal particle size and water dispersibility, thus optimizing their biological applicability. To investigate the potential for in-vivo application, we employed RALO-F@F127 NPs as a representative model. The afterglow of the RALO-F@F127 NPs enables clear tumor visualization with a distinct signal-to-noise ratio, which is hardly attainable with fluorescence imaging. By virtue of their RTP properties, this work effectively circumvents tissue autofluorescence interference, thereby establishing an innovative platform for in-vivo afterglow imaging.