文献类型：期刊文献

英文题名：Biocatalytic ketone reduction: A green and efficient access to enantiopure alcohols

作者：Ni, Yan[1];Xu, Jian-He[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Biocatalysis & Synthet Biotechnol, Shanghai 200237, Peoples R China

年份：2012

卷号：30

期号：6

起止页码：1279

外文期刊名：BIOTECHNOLOGY ADVANCES

收录：;EI(收录号：20124315605328);WOS:【SCI-EXPANDED(收录号:WOS:000311859100009)】；

基金：Thanks to the financial supports from National Natural Science Foundation of China (nos. 31071604 and 20902023), Ministry of Science and Technology, P.R. China (nos. 2011CB710800, 2011AA02A210) and China National Special Fund for State Key Laboratory of Bioreactor Engineering (no. 2060204).

语种：英文

外文关键词：Asymmetric reduction; Biocatalysis; Chiral alcohols; Genome mining; Reductases

摘要：Chiral secondary alcohols play an important role in pharmaceutical, agrochemical, and chemical industries. In recent years, impressive steps forward have been achieved towards biocatalytic ketone reduction as a green and useful access to enantiopure alcohols. An increasing number of novel and robust enzymes are now accessible as a result of the ongoing progress in genomics, screening and evolution technologies, while process engineering provides further success in areas of biocatalytic reduction in meeting synthetic challenges. The versatile platform of these techniques and strategies offers the possibility to apply high substrate loading and thus to overcome the limitation of low volumetric productivity of usual enzymatic processes which is the bottleneck for their practical application. In addition, the integration of bioreduction with other enzymatic or chemical steps allows the efficient synthesis of more complex chiral products. (c) 2011 Elsevier Inc. All rights reserved.