文献类型：期刊文献

英文题名：Practical cuprous catalyzed anti-Markovnikov difluoroacetamidation of α-(trifluoromethyl)styrenes

作者：Zeng, Qian-Ding[1];Yao, Hongmiao[1];Yuan, Xinxin[1];Wang, Jian[1];Zeng, Bu-Bing[1];Ren, Jiangmeng[1];Yang, Wu-Lin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai, Peoples R China

年份：2024

卷号：151

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001333886100001)，CCR-EXPANDED(收录号:WOS:001333886100001)】；

基金：This work was financially supported by Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) .

语种：英文

外文关键词：Cuprous catalysis; Anti-Markovnikov; Difluoroacetamidation; alpha-(Trifluoromethyl)styrene; 2,2,5,5,5-Pentafluoro pentanamides

摘要：An anti-Markovnikov difluoroacetamidation of alpha-(trifluoromethyl)styrenes was successfully performed, yielding 2,2,5,5,5-pentafluoropentanamides in good yields. This reaction was catalyzed by CuBr in the presence of pentamethyldiethylenetriamine (PMDETA) in MeCN, conducted under a nitrogen atmosphere. To assess the influence of substituent groups on the aromatic ring, two series of substrates were tested within the developed catalytic system. Additionally, scale-up applications and mechanistic studies were carried out.