文献类型：期刊文献

英文题名：Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling

作者：Ma, Yueyue[1,2,3,4];Hong, Jufei[1,2];Yao, Xiantong[1,2];Liu, Chengyu[1,2];Zhang, Ling[1,2];Fu, Youtian[1,2];Sun, Maolin[1,2];Cheng, Ruihua[1,2,5];Li, Zhong[3];Ye, Jinxing[1,2,4]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[4]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：23

期号：24

起止页码：9387

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000731622200001)，CCR-EXPANDED(收录号:WOS:000731622200001)】；

基金：This work was partially sponsored by the Shanghai Sailing Program (20YF1410400), the Shanghai Postdoctoral Excellence Program, the National Natural Science Foundation of China (22071056 and 22001070), and the China Postdoctoral Science Foundation (2020T130189).

语种：英文

摘要：We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp2)-C(sp3) bonds.