文献类型：期刊文献

英文题名：Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways

作者：Sun, Lijuan[1]; Liu, Jianwen[1]; Liu, Ping[2]; Yu, Youjun[1]; Ma, Lei[1]; Hu, Lihong[3]

机构：[1] State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [2] LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China; [3] Shanghai Innovative Research Center of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

年份：2011

卷号：46

期号：2

起止页码：482

外文期刊名：Process Biochemistry

收录：EI(收录号：20110113546659)

语种：英文

外文关键词：Porphyrins

摘要：Withangulatin A (WA), a bioactive withanolide isolated from Physalis angulata L., has a strong immunosuppressive activity. We have demonstrated that WA significantly suppressed the over-proliferation of ConA-induced T lymphocytes in a dose- and time-dependent manner, which modulated Th1/Th2-type balance dramatically. Moreover, WA-induced heme oxygenase 1 (HO-1) expression in mice T lymphocytes through the ERK/MAPK pathway and inhibited ConA-induced nuclear factor κB (NF-κB p65) nuclear translocation, directly or indirectly mediated by HO-1. Notably, WA affected the expression of COX-2 and PPAR-γ in ConA-induced T lymphocytes. The synergistic manner in which WA enhanced HO-1 expression through the ERK/MAPK pathway and NF-κB nuclear translocation and other regulatory proteins, thereby restricting T lymphocytes from over-expression and modulating Th1/Th2-type balance, could be the mechanism for the immunosuppressive properties of WA, the immunosuppressive effect of which may protect against autoimmune disorder diseases. ? 2010 Elsevier Ltd.