文献类型：期刊文献

英文题名：Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

作者：Li, Hui[1];Lu, Aoyun[1];Zhang, Yanqiu[1];Peng, Yanqing[1];Song, Gonghua[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：195

期号：5

起止页码：371

外文期刊名：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000503931100001)】；

基金：Financial support for this study from the National Natural Science Foundation of China (Grant No. 21572060) is gratefully acknowledged.

语种：英文

外文关键词：Azabicyclo; PWNs; nematicidal activity; novel nematicide

摘要：To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.