文献类型：期刊文献

英文题名：Facile synthesis of N-phenoxycarbonyl amino acids by a two-phase reaction for direct polymerization

作者：Zhang, Donghui[1,2];Liu, Shiqi[1,3];Cai, Zhihao[1,3];Luo, Weizhe[1,3];Liu, Guojian[1,3];Liu, Runhui[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Key Lab Ultrafine Mat Minist Ed, Shanghai 200237, Peoples R China

年份：2024

卷号：15

期号：2

起止页码：97

外文期刊名：POLYMER CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001114295800001)】；

基金：This research was supported by the National Key Research and Development Program of China (2022YFC2303100), the National Natural Science Foundation of China (No. 22075078 and 22205063), the Shanghai Sailing Program (22YF1410100), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), and the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (the Shanghai Municipal Education Commission). The authors also thank the Research Center of Analysis and Test of the East China University of Science and Technology for helping with the characterization.

语种：英文

摘要：Polypeptides are extensively used in the fields of biomedicine and biomaterials. The use of N-phenoxycarbonyl amino acids (NPCs) as monomers for polypeptide synthesis is an advanced method that offers the unique advantage of excellent monomer stability. However, the purification of NPC monomers previously required laborious column chromatography or recrystallization techniques, which might have restricted the widespread application of NPC polymerization. In this work, a straightforward and efficient method for synthesizing NPC monomers has been developed, enabling the production of products with high purity through a simple work-up process. This method is compatible with various amino acids, and the resulting monomers can undergo normal polymerization reactions. By significantly enhancing the availability of NPC monomers, this method facilitates the synthesis of polypeptides.