文献类型：期刊文献

英文题名：Synthesis of 1,3,5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate]pyrazoles via a Pd-Catalyzed C-H Activation

作者：Wang Xiaoguang[1,2];Fang Xiang[1,2];Yang Xueyan[1,2];Ni Meng[1,2];Wu Fanhong[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China

年份：2012

卷号：30

期号：12

起止页码：2767

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000312942500008)，CCR-EXPANDED(收录号:WOS:000312942500008)】；

基金：This work is supported by the National Natural Science Foundation of China (Nos. 20972050, 21172148 and 21202044) and the Science and Technology Commission of Shanghai Municipality (No. 10540501300).

语种：英文

外文关键词：C?H activation; Pd-catalyzed; pyrazole; HMG-CoA reductase inhibitor

摘要：The gem-difluoromethylenated acetonide 2 was efficiently synthesized as new precursor of HMG-CoA reductase inhibitor. Straightforward olefination via Pd-catalyzed C4-H activation of 1,3,5-trisubstituted pyrazoles 1 was proceeded smoothly in the presence of Pd(OAc)2 and AgCO3. This protocol has merits in terms of the improved atomic economy and prevention from the generation of by-products.