文献类型：期刊文献

英文题名：Triggering Sequential Catalytic Fenton Reaction on 2D MXenes for Hyperthermia-Augmented Synergistic Nanocatalytic Cancer Therapy

作者：Liang, Ruijie[1];Li, Yongsheng[1];Huo, Minfeng[2];Lin, Han[2];Chen, Yu[2]

机构：[1]East China Univ Sci & Technol, Lab Low Dimens Mat Chem,Key Lab Ultrafine Mat, Shanghai Engn Res Ctr Hierarch Nanomat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2019

卷号：11

期号：46

起止页码：42917

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20194607672895);WOS:【SCI-EXPANDED(收录号:WOS:000499740300006)】；

基金：We greatly acknowledge the financial support from the National Key R&D Program of China (Grant No. 2016YFA0203700), National Nature Science Foundation of China (Grant Nos. 51672303, 51722211, 51461165202, and 51472085), Young Elite Scientist Sponsorship Program by CAST (Grant No. 201SQNRC001), the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), and The Fundamental Research Funds for Central Universities (222201718002).

语种：英文

外文关键词：nanocatalytic therapy; photothermal conversion; MXene; Fenton reaction; nanomedicine

摘要：The unique characteristics of a tumor microenvironment (TME) enable the development of new tumortherapeutic modalities with high efficiency, biosafety, and tumor specificity. In this work, we report on the construction of photothermal-enhanced and nanocatalyst-enabled sequential catalytic reaction for TME-specific cancer therapy. This conceptual advance is achieved by engineering the surface of two-dimensional Ti3C2 MXene with two separate catalysts, including natural glucose oxidase (GOD) as glucose catalysts and superparamagnetic iron oxide nanoparticles (IONPs) as Fenton-reaction nanocatalysts. A sequential catalytic reaction is triggered by using GOD for catalyzing the tumor-overtaken glucose to generate large amounts of hydrogen peroxide molecules. Subsequently IONPs can catalyze the transformation of pregenerated hydrogen peroxide into large amounts of highly toxic hydroxyl radicals to kill the cancer cells subsequently in TME-enabled acidity condition. The two-dimensional (2D) Ti3C2 MXene matrix efficiently converts the near-infrared light into thermal energy to synergistically enhance the catalytic efficiency of this sequential catalytic reaction and therefore achieve the high synergistic cancer-therapeutic outcome, accompanied with the high biocompatibility of the constructed composite nanocatalysts. Both in vitro cancer-cell evaluation and in vivo tumor xenograft on nude mice with complete tumor eradication demonstrate the high synergistic efficiency of photothermal-enhanced sequential nanocatalytic cancer therapy. Therefore, this work substantially broadens the biomedical applications of 2D MXenes to nanocatalytic cancer therapy by enhancing the Fenton reaction-based nanocatalytic therapy via converting the near-infrared light into thermal energy and subsequently elevating the local Fenton-reaction temperature.