文献类型：期刊文献

英文题名：Zr-Based MOFs Shielded with Phospholipid Bilayers: Improved Biostability and Cell Uptake for Biological Applications

作者：Yang, Jian[1];Chen, Xiaojing[2,3];Li, Yongsheng[1];Zhuang, Quxin[1];Liu, Peifeng[2,3];Gu, Jinlou[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai 200032, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Cent Lab, Shanghai 200127, Peoples R China

年份：2017

卷号：29

期号：10

起止页码：4580

外文期刊名：CHEMISTRY OF MATERIALS

收录：;EI(收录号：20172203709818);WOS:【SCI-EXPANDED(收录号:WOS:000402498000049)】；

基金：This work was financially supported by the Natural Science Foundation of China (Grants 51372084, 81472842, and 81502560) and the 111 Project (Grant B14018).

语种：英文

外文关键词：Cell culture - Crystalline materials - Phospholipids - Medical applications - Organometallics - Biocompatibility - Zirconium compounds

摘要：For practical biomedical applications, the stabilization of nanoscale metal organic frameworks (NMOFs) in the presence of phosphate is of prime importance but remains a significant challenge because of the inevitable and strong driving force between metal clusters and phosphate species to form metal phosphate in physiological environments. Through shielding Zr-NMOFs within the continuous phospholipid bilayers (PBLs), herein, we figured out a unique way to protect the vulnerable coordination bonds in their frameworks from the attack of phosphate. To exemplify the facility of constructing PBLs on Zr-NMOFs core, a porphyrinic NMOF of PCN-223 (standing for a platform with broad biological applications) was elaborated using a triethylamine (TEA)-modulated strategy. TEA could not only control the phase transformation of porphyrinic MOFs to achieve pure-phase PCN-223 crystals but also minimize their particles size down to sub-200 run. Negative-stained TEM, FT-IR and XPS techniques revealed that PBLs could be closely coated onto the surface of nanoPCN-223, thanks to the strong Zr-O-P chemical complexation between Zr-NMOFs and phospholipid. The resultant coated nanoPCN-223 exhibited significantly enhanced phosphatic-resistance in phosphate buffer solution (PBS) and presented exceptional stability in harsh chemical environments. Furthermore, the MOFs-supported PBLs could effectively provide a stable biocompatible interface for subsequent cell culture and improve their biocompatibility, cellular uptake efficiency and real biostability of NMOFs in cellular environments. This study offers an alternative system for forming stable PBLs supported on NMOFs, and represents the first example of stabilizing Zr-NMOFs free from the attack of phosphate species in biological media.