文献类型：期刊文献

英文题名：Mechanical Strength, Surface Properties, Cytocompatibility and Antibacterial Activity of Nano Zinc-Magnesium Silicate/Polyetheretherketone Biocomposites

作者：Tang, Xiaoming[1];Dai, Jian[1];Sun, Hailang[1];Saha, Nabanita[2];Saha, Petr[2];Wang, Deqiang[3];Cheng, Qinlin[3];Wei, Jie[3]

机构：[1]Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Orthoped, Huaian 223300, Jiangsu, Peoples R China;[2]Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Zlin, Czech Republic;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2019

卷号：19

期号：12

起止页码：7615

外文期刊名：JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000473105800015)】；

基金：The grants were from the National Natural Science Foundation of China (51772194 and 81771990), Key Medical Program of Science and Technology Development of Shanghai (15441902500 and 17441902000) as well as by the Ministry of Education, Youth and Sports of the Czech Republic-Program NPU I (LO1504).

语种：英文

外文关键词：Polyetheretherketone; Nano Zinc-Magnesium Silicate; Cytocompatibility; Antibacterial Activity

摘要：In order to improve the biological activity and antibacterial properties of polyetheretherketone (PK) as bone implants, nano zinc-magnesium silicate (nZMS)/PK bioactive composites (nZPC) were fabricated. The results revealed that the mechanical properties, surface roughness and hydrophilicity of the nZPC gradually increased with nZMS content, in which nZPC with 50 w% of nZMS (50nZPC) exhibited the best properties. In addition, incorporation of nZMS into PK significantly improved the apatite mineralization ability of nZPC, which depended on nZMS content. Moreover, the attachment, proliferation and differentiation of MC3T3-E1 cells on nZPC were significantly enhanced with increasing nZMS content. Furthermore, after incorporation of nZMS into PK, the nZPC could inhibit the growth of Escherichia coli (E. coli), in which 50nZPC revealed the best antibacterial activity. The results suggested that 50nZMPC with good bioactivity, cytocompatibility and antibacterial activity might be a promising candidate as an implant for bone repair and anti-infection.