文献类型：期刊文献

中文题名：超临界抗溶剂法制备微粒的机理研究

英文题名：Fundamentals and Mechanisms of Micronization with Supercritical Anti-solvent Process(SAS)

作者：李广田[1];陈岚[1];蔡建国[2];刘哲鹏[1]

机构：[1]上海理工大学医疗器械与食品学院,上海200093;[2]华东理工大学化工学院,上海200237

年份：2009

卷号：50

期号：12

起止页码：751

中文期刊名：化学世界

外文期刊名：Chemical World

收录：北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：上海市研究生创新基金项目(No.JWCXSL0802);上海高校特聘教授(东方学者)岗位计划资助

语种：中文

中文关键词：超临界抗溶剂法;相平衡;射流;传质;成核结晶;数学模型

外文关键词：supercritical anti-solvent process; equilibrium; hydrodynamics; mass transfer; nucleation numerical modeling

摘要：超临界抗溶剂法是一种新型环保、具有广阔应用前景的微细颗粒制备技术,在材料科学、食品工业及药物微粒制备方面的应用成为研究的热点。随着实验研究中众多问题的出现,其理论研究越来越被重视,并且取得了一定的进展。着重从体系相平衡及溶液和超临界CO2之间的混合行为等方面,综述了近年来国内外对超临界抗溶剂法制备微细颗粒过程的理论研究进展并分析了部分存在问题。
SAS has been recognized as a new environmentally benign technique and an alternative to conventional particle formation methods in many fields. However, there are still many problems restrained the advanced development of SAS. These problems can be ascribed to lacking of correct understanding and theoretical interpretation of SAS involving numerical modeling of the thermodynamic description of multi-phase systems, hydrodynamic computation about jet breakup and mass transfer. It reviewed the theoretical developments in the recent years and proposed some pending tasks which should be done in the future.