文献类型：期刊文献

英文题名：A positively charged porous graphitic carbon stationary phase for hydrophilic interaction liquid chromatography

作者：Hou, Yanjie[1];Zhang, Feifang[1];Liu, Xuefang[1];Ren, Yanjun[2];Yang, Bingcheng[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China

年份：2017

卷号：164

起止页码：159

外文期刊名：TALANTA

收录：;EI(收录号：20164803076029);WOS:【SCI-EXPANDED(收录号:WOS:000393244400024)】；

基金：The research was sponsored by National Natural Science Foundation of China (No. 21322502, 21477037). The authors gratefully acknowledge support from the outstanding young talent cultivation fund of ECUST. The authors are also grateful to Dr. Xiaodong Liu (Thermo Fisher Scientific) for a gift of porous graphitic carbon particles.

语种：英文

外文关键词：Hydrophilic interaction liquid chromatography; Stationary phase; Positively charged; Polyvinyl alcohol

摘要：High chemical inertness of porous graphitic carbon particles (PGC) makes their surface modification rather difficult. Here a facile way is proposed to prepare a PGC stationary phase with quaternary ammonium-polyvinyl alcohol mixed functional groups for hydrophilic interaction liquid chromatography (HILIC) by generating a thin layer of polyvinyl alcohol (PVA) and poly(diallyldimethylammonium chloride) (DDAC) copolymer onto PGC particles. The phase shows obvious positively electrostatic character and typical HILIC character, exhibiting different selectivity relative to several HILIC phases and bare PGC. To the best of our knowledge, this is the first fully pH-stable, quaternary ammonium functionalized HILIC phase. It is much superior to silica-based HILIC phases in terms of wide pH tolerance (2.1-12.7) and low bleeding.