文献类型：期刊文献

英文题名：A proton-responsive ensemble using mesocellular foam supports capped with N, O-carboxymethyl chitosan for controlled release of bioactive proteins

作者：Gan, Qi[1,2,3,4];Zhu, Jiaoyang[1,2];Yuan, Yuan[1,2];Liu, Honglai[3,4];Zhu, Yihua[2];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Biomed Engn Res Ctr, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：3

期号：11

起止页码：2281

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20151100631790);WOS:【SCI-EXPANDED(收录号:WOS:000350983400003)】；

基金：The authors wish to express their gratitude for the financial support from National Basic Research Program of China (973 Program, no. 2012CB933600), the 111 Project (B14018), National Natural Science Foundation of China (no. 31470924 and no. 31400817), and Chinese Postdoctoral Science Foundation (2013M541484). This study was also supported by Program for New Century Excellent Talents in University (no. NCET-11-0640) and the National Special Fund for the State Key Laboratory of Bioreactor Engineering (no. 2060204).

语种：英文

外文关键词：Chitosan - Proteins

摘要：A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-soluble N, O-carboxymethyl chitosan via the crosslinking of GPTMS. The delivery systems show excellent protein loading with programmable release in an acid environment. Moreover, the released proteins still preserve their conformational and biological activity.