文献类型：期刊文献

英文题名：A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols

作者：Zhou, Ding[1,2];Huang, Zheng[1,2];Yu, Xueting[1,2];Wang, Youxin[2];Li, Jian[2];Wang, Wei[1,2,3];Xie, Hexin[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2015

卷号：17

期号：22

起止页码：5554

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000365462900011)，CCR-EXPANDED(收录号:WOS:000365462900011)】；

基金：This project was financially supported by the "Thousand Plan" Youth Program, the Fundamental Research Funds for the Central Universities and East China University of Science and Technology.

语种：英文

摘要：A highly enantioselective aza-Friedel-Crafts (aza-F-C) reaction of cyclic trifluoromethyl ketimines and naphthols/phenols was developed with fluorenyl-substituted quinine-squaramide as the catalyst. This protocol enables direct access to biologically important chiral trifluoromethyl dihydroquinazolinones with up to 99% yields and up to 99% ee's.