文献类型：期刊文献

中文题名：乳糖-纤维素复合辅料的制备及其性能评价

英文题名：Preparation and properties of a co-processed compound based on lactose and cellulose

作者：胡晏[1];张玲[1];顾纪明[2];余伟民[3];崔景斌[1]

机构：[1]华东理工大学药学院,上海200237;[2]上海美优制药有限公司,上海100055;[3]上海天宸药业有限公司,上海201203

年份：2007

卷号：19

期号：10

起止页码：6

中文期刊名：海峡药学

外文期刊名：Strait Pharmaceutical Journal

语种：中文

中文关键词：复合辅料;直接压片;乳糖;纤维素;结晶

外文关键词：Co-processed compound; Direct compression; Lactose; Cellulose; Crystallization

摘要：目的制备乳糖-纤维素复合辅料,用于直接压片技术。方法通过乳糖结晶工艺制备质量比为75∶25的乳糖-纤维素复合辅料。比较复合辅料与简单混合物的粉体学性质以及片剂质量。结果复合辅料显示出较好的流动性、填充性和可压性,对可压性差的药物具有很好的稀释作用。结论乳糖-纤维素复合辅料通过对乳糖及粉状纤维素物理性能的改变,更加适用于直接压片工艺。
OBJECTIVE Lactose and cellulose compound with the ratio of 75：25 was prepared for direct compression. METHODS The compound was prepared with crystallization and it was compared to the physical blend to evaluate the properties. RESULTS The compound exhibited good flowability, packing rate, compressibillity and excellent dilution potential. CONCLUSION The compound was superior to physical blend and it was suitable for direct compression.