文献类型：期刊文献

英文题名：Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium (KATP)

作者：Zhu, Zhirong[1,2];Wang, Qi[1,2];Liao, Hongze[3];Liu, Ming[1,2];Liu, Zhenxing[1,2];Zhang, Youheng[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn Feringa, Sch Chem & Mol Engn,Frontiers Sci Ctr Materiobiol, Inst Fine Chem,Feringa Nobel Prize Scientist Join, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Ren Ji Hosp, Res Ctr Marine Drugs, Sch Med,State Key Lab Oncogene & Related Genes,De, Shanghai 200127, Peoples R China

年份：2021

卷号：8

期号：6

外文期刊名：NATIONAL SCIENCE REVIEW

收录：;EI(收录号：20214711213583);WOS:【SCI-EXPANDED(收录号:WOS:000706946700007)】；

基金：This work was supported by National Natural Science Foundation of China (NSFC) Science Center Program (21788102), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), NSFC Major Research Project (91959202), National Key Research and Development Program (2016YFA0200300), NSFC/China (21974047 and 21622602), Shanghai Pujiang Program (19PJ1402300), China Postdoctoral Science Foundation (2020M671328), Fundamental Research Funds for the Central Universities (222201814013), and Postdoctoral Science Foundation of Jiangsu Province (2020Z189).

语种：英文

外文关键词：aggregation-induced emission; amphiphilic AIEgens; endoplasmic reticulum; targeting specificity; high-fidelity tracking

摘要：The current aggregation-induced emission luminogens (AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with 'always-on' fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence. Herein, we report an unprecedented 'amphiphilic AIEgen' sensor QM-SO3-ER based on the AIE building block of quinoline-malononitrile (QM). The introduced hydrophilic sulfonate group can well control the specific solubility in a hydrophilic system with desirable initial 'fluorescence-off' state. Moreover, the incorporated p-toluenesulfonamide group plays two roles: enhancing the lipophilic dispersity, and behaving as binding receptor to the adenosine triphosphate (ATP)-sensitive potassium (K-ATP) on the endoplasmic reticulum (ER) membrane to generate the docking assay confinement effect with targetable AIE signal. The amphiphilic AIEgen has for the first time settled down the predicament of unexpected 'always-on' fluorescence in the aqueous system and the untargetable aggregation signal in the lipophilic organelle before binding to ER, thus successfully overcoming the bottleneck of AIEgens' targetability.