文献类型：期刊文献

英文题名：Ligand-free Cu-catalyzed [3+2] cyclization for the synthesis of pyrrolo[1,2-a]quinolines with ambient air as a terminal oxidant

作者：Yu, Yang[1,2];Liu, Yuan[1,2];Liu, Aoxia[1,2];Xie, Hexin[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2016

卷号：14

期号：31

起止页码：7455

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20163302708661);WOS:【SCI-EXPANDED(收录号:WOS:000381419700006)，CCR-EXPANDED(收录号:WOS:000381419700006)】；

基金：Financial support of this research from the program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning (no. 201226, H. L.), the National Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and the China 111 Project (Grant B07023) is gratefully acknowledged.

语种：英文

外文关键词：Catalysis - Chelation - Ligands - Oxidants

摘要：A ligand-free Cu-catalyzed [3 + 2] cycloaddition of ethyl 2-(quinolin-2-yl)acetates, ethyl 2-(isoquinolin-1-yl)acetates, and ethyl 2-(pyridin-2-yl)acetates with (E)-chalcones for a "one-pot" synthesis of pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines and indolizines has been developed. The annulation products were isolated in moderate to good yields with air as the sole oxidant under mild conditions.