文献类型：期刊文献

英文题名：Highly selective visible-light-induced cascade cyclization of vinyl sulfoxonium ylides with azides: a novel synthetic approach towards trisubstituted furans

作者：Cui, Jia-Huan[1];Tan, Mei[1];Zhang, Jun[1];He, Yan[2];Li, Xingguang[1];Liu, Pei-Nian[1,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China;[3]China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China

年份：2025

卷号：12

期号：6

起止页码：1905

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20250417753502);WOS:【SCI-EXPANDED(收录号:WOS:001399343200001)】；

基金：The authors are grateful to the National Natural Science Foundation of China (22201073, 21925201, and 22161160319) and the Fundamental Research Funds for the Central Universities. The authors thank the Research Center of Analysis and Test of the East China University of Science and Technology for help with the characterization.

语种：英文

外文关键词：Light metals - Regioselectivity - Scaffolds (biology) - Synthesis (chemical)

摘要：A simple protocol for the synthesis of trisubstituted furans via visible-light-driven regioselective cascade cyclization of vinyl sulfoxonium ylides with azides has been achieved. The reaction proceeds through the formation of a novel alpha-enone-alpha '-amide sulfoxonium ylide, which undergoes cyclization upon blue light irradiation to yield a trisubstituted furan scaffold. This method offers advantages including the absence of transition metals and photocatalysts, and the desired trisubstituted furans were prepared in good to excellent yields.