文献类型：期刊文献

英文题名：Extensive in vitro activity of guanidine hydrochloride polymer analogs against antibiotics-resistant clinically isolated strains

作者：Zhou, Zhongxin[3];Wei, Dafu[4];Guan, Yong[4];Zheng, Anna[4];Zhong, Jian-Jiang[1,2,3]

机构：[1]Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China;[3]E China Univ Sci & Technol, Sch Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2011

卷号：31

期号：8

起止页码：1836

外文期刊名：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000297400800033)】；

基金：The authors gratefully acknowledge Dr. Xiaofei Jiang (Huashan Hospital, Shanghai Medical College, Fudan University) for his supplying all clinical strains. The authors are also grateful to the financial support by the National Natural Science Foundation of China (Nos. 30821005 & 50573020) and the Shanghai Leading Academic Discipline Project (project nos. B203 & B505).

语种：英文

外文关键词：Cationic guanidine polymer; Antimicrobial activity; Antibiotics resistance

摘要：Polyhexamethylene guanidine hydrochloride (PHMG) possesses great potential in the development of covalently bound permanent sterile-surface materials for hospital infection control. This study aimed at evaluating the extensive activity of PHMG and its three novel analogs, including polybutamethylene guanidine hydrochloride, polyoctamethylene guanidine hydrochloride (POMG) and poly(m-xylylene guanidine hydrochloride), against 370 clinical strains, especially 96 isolates of which were antibiotics-resistant. Their in vitro antimicrobial activities were determined by testing the minimal inhibitory concentration (MIC) and time-killing curves. POMG, the novel oligoguanidine had significantly lower MIC values (0.5-16 mg/L) against 370 antibiotics-susceptible and -resistant clinical strains compared to PHMG (1-64 mg/L) and chlorhexidine digluconate (2-64 mg/L). Interestingly. POMG displayed excellent activity against meticillin resistant-Staphylococcus aureus (1-8 mg/L) and -coagulase-negative staphylococci (1-2 mg/L), vancomycin resistant Enterococcus faecium (2-4 mg/L), multidrug resistant Pseudomonas aeruginosa (8-16 mg/L), ceftazidime resistant-Citrobacter spp. (1-4 mg/L) and -Enterobacter spp. (2-4 mg/L). PHMG was especially efficient against methicillin resistant-S. aureus and -coagulase-negative staphylococci (1-8 mg/L). The presented extensive activity of POMG and PHMG against antibiotic-resistant bacteria provides encouraging reference information for the using and further development of cationic guanidine-based polymers in the biomedical material field. (C) 2011 Elsevier B.V. All rights reserved.