文献类型：期刊文献

英文题名：Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

作者：Zhang, Zhongyin[1,2];Yang, Fan[2];Fu, Jian-Jun[2];Shen, Yun-Heng[1];He, Weiwei[2];Zhang, Wei-Dong[1,2]

机构：[1]Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：6

期号：70

起止页码：65885

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20163002636731);WOS:【SCI-EXPANDED(收录号:WOS:000379577800070)】；

基金：The work was supported by Professor of Chang Jiang Scholars Program, Ministry of Science & Technology (2013CB836900), National Natural Science Foundation of China (81230090, 81520108030, 81573318, 81373301, 81302658, 81502956, and 21572064), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), the Scientific Foundation of Shanghai China (12401900801 and 13401900101), Shanghai Science and Technology Commission (15PJ1401300), National Major Project of China (2011ZX09307-002-03), and the National Key Technology R&D Program of China (2012BAI29B06).

语种：英文

外文关键词：Bioactivity - Drug products - Metabolites - Cell culture - Spectroscopic analysis

摘要：Natural products have long been an important source for the discovery of biologically active compounds, in particular, drug leads. Delavatine A (1), a structurally unusual cyclopenta[de]isoquinoline alkaloid, was isolated from Incarvillea delavayi. Extensive spectroscopic analysis, in combination with biogenetic speculation, established the structure of 1. Delavatine A (1) exhibited considerable cytotoxicity against a number of cancer cell lines with IC50 values in the range of 4.28 to 6.61 mu g mL(-1).