文献类型：期刊文献

英文题名：A simple monoselective C-H oxygenation approach for the synthesis of ursane triterpenoids

作者：Mei, Wenyi[1];Fan, Sisi[1];Han, Yufei[1];Shi, Cunjian[1];Qiu, Lijie[1];Shen, Yunheng[2];Zhao, Zhenjiang[1];Xu, Yufang[1];Li, Honglin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Naval Med Univ, Sch Pharm, Dept Phytochem, 325 Guohe Rd, Shanghai 200433, Peoples R China

年份：2023

卷号：21

期号：7

起止页码：1395

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20230513499742);WOS:【SCI-EXPANDED(收录号:WOS:000928989800001)，CCR-EXPANDED(收录号:WOS:000916792700001)】；

基金：The research is supported in part by the National Natural Science Foundation of China (grants 81825020 and 82150208 to H. L.). We thank Prof. Ang Li (Shanghai Institute of Organic Chemistry) for their critical comments on the manuscript.

语种：英文

摘要：Herein, we presented a simple approach for C-H oxidation in the C23 or/and C24 of ursane triterpenoids without any protection of a Delta(12,13) double bond. As a result, from commercial ursolic acid (UA), six naturally occurring ursane triterpenoids were synthesized in overall yields of 3.4% to 36.8%, which implied the importance of this approach for the derivation of natural products and their application in biological activity.