文献类型：期刊文献

英文题名：Palladium-Catalyzed (3+2) Annulation of Aromatic Acids by C(sp3)-H Olefination and Decarboxylative Cross-Coupling Reaction

作者：Xu, Xiaobo[1,2];Wang, Yangyang[1,2];Yu, Xiao[1,2];Liu, Xian[1,2];Hao, Liqiang[1,2];Ji, Yafei[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2024

卷号：26

期号：7

起止页码：1338

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001167175200001)，CCR-EXPANDED(收录号:WOS:001167175200001)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

摘要：A palladium-catalyzed (3 + 2) annulation of 2-methylbenzoic acid with maleimide using Ac-Leu-OH as a powerful ligand has been reported. Through a site-selective gamma-C(sp(3))-H olefination reaction and a sequential decarboxylative cross-coupling reaction, a five-membered cyclic ring was obtained as the final product. This novel reaction features great site selectivity and reactivity to generate various cyclic products in moderate to good yields.