文献类型：期刊文献

中文题名：Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

英文题名：氧化钼的限域调控及其肿瘤光热治疗研究

作者：Limei Qin[1];Dechao Niu[1];Xing Qin[1];Qiqi Sun[1];Zicong Wen[1];Qili Yu[1];Yongsheng Li[1,3];Jianlin Shi[1,2]

机构：[1]Lab of Low-Dimensional Materials Chemistry,Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]State Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China;[3]Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,School of Chemistry and Chemical Engineering,Shihezi University,Shihezi 832003,China

年份：2021

卷号：64

期号：12

起止页码：3087

中文期刊名：Science China Materials

外文期刊名：中国科学（材料科学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：This work was supported by the National Key Research and Development Program of China (2016YFA0203700), the National Natural Science Foundation of China (51672083, 51962022 and 52072124), the Natural Science Foundation of Shanghai (20ZR1414900), the Program of Shanghai Academic/Technology Research Leader (18XD1401400), the Leading Talents in Shanghai in 2018, and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the 111 Project (B14018).

语种：英文

中文关键词：confinement effect;porous silica nanoreactor;molybdenum oxide;oxygen deficiency;photothermal therapy

外文关键词：纳米反应器;多孔二氧化硅;氧化钼;多孔氧化硅;等离子共振吸收;介孔二氧化硅;近红外吸收;光热治疗;

摘要：Molybdenum oxide nanoparticles(NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However,fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein,we have developed an "in-situ confined oxidation-reduction"strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor(designated as MoO_(3)@PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in nearinfrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO_(3)@PPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO_(3)NPs in a biocompatible porous silica nanoreactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.
氧化钼纳米材料在近红外区域具有可调节的等离子共振吸收,并表现出优异的半导体特性和光热特性,这与其晶体结构和表面氧缺陷息息相关.然而,氧化钼晶体结构/氧缺陷和光热性能之间的关系仍不清楚.基于此,我们发展了一种简便的"原位限域氧化-还原"策略来精准调控双介孔二氧化硅纳米反应器中氧化钼纳米颗粒的晶体结构及缺陷位点.通过调节钼源的引入量和还原温度,详细研究了氧化钼的晶体结构/氧缺陷对其光热性能的影响.作为一种光热转换材料,聚乙二醇(PEG)修饰且负载缺陷态氧化钼的多孔氧化硅纳米颗粒(MoO_(3)-x@PPSNs)在近红外吸收范围内表现出良好的生物相容性和较强的局域表面等离子共振(LSPR)效应,808 nm激光下的光热转换效率可达78.7%,并在细胞及活体水平验证了其优异的光热性能.因此,我们认为这种生物相容性多孔二氧化硅纳米反应器中的等离子MoO_(3)-x纳米粒子可以作为一种有效的光热试剂用于肿瘤的光热消融.