文献类型：期刊文献

英文题名：Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds

作者：Ai, Wen[1,2,3];Yang, Xueyan[2,3];Wu, Yunxiang[1];Wang, Xuan[1];Li, Yuanchao[1];Yang, Yaxi[1];Zhou, Bing[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：20

期号：52

起止页码：17653

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20150200406575);WOS:【SCI-EXPANDED(收录号:WOS:000346468000046)，CCR-EXPANDED(收录号:WOS:000346468000046)】；

基金：Support of this work by the National Natural Science Foundation of China (No. 21302200) is gratefully acknowledged.

语种：英文

外文关键词：alkylation; C-H activation; indolines; iridium; rhodium

摘要：A Rh-III-catalyzed procedure for the C7-selective C-H alkylation of various indolines with alpha-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N-2 as the sole by-product. Furthermore, alkylation and bis-alkylation of carbazoles at the C1 and C8 positions have also been developed. More significantly, for the first time, a successful Ir-III-catalyzed intermolecular insertion of arene C-H bonds into a-diazo compounds is reported.