文献类型：期刊文献

英文题名：Mathematical Modeling and Analysis of Crosstalk between MAPK Pathway and Smad-Dependent TGF-beta Signal Transduction

作者：Liu, Ji[1,2];Dai, Wei[2,3,4];Hahn, Juergen[2,3,4]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab, Shanghai 200237, Peoples R China;[2]Rensselaer Polytechn Inst, Ctr Biotechnol & Interdisciplinary Studies, 110 8th St, Troy, NY 12180 USA;[3]Rensselaer Polytechn Inst, Dept Biomed Engn, Troy, NY 12180 USA;[4]Rensselaer Polytechn Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

年份：2014

卷号：2

期号：3

起止页码：570

外文期刊名：PROCESSES

收录：WOS:【ESCI(收录号:WOS:000218628600003)】；

语种：英文

外文关键词：crosstalk; MAPK pathway; Smad-dependent TGF-beta signal transduction; model of the pathway

摘要：Broad evidence exists for cross talk between the Mitogen-activated protein kinases (MAPK) pathway and Smad-dependent TGF-beta signal transduction. A variety of studies, oftentimes involving different cell types, have identified several potential mechanisms for the crosstalk. However, there is no clear consensus on the actual mechanism(s) responsible for the crosstalk. This work develops a model of the pathway, including several hypothesized crosstalk mechanisms, and discusses which of the potential mechanisms can appropriately describe observed behaviors. Simulation results show a good agreement of the findings with results reported in the literature.