文献类型：期刊文献

英文题名：Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021

作者：Yang, Jin[1];Gong, Lizhi[1];Guo, Miaomiao[2];Jiang, Yu[1];Ding, Yi[1];Wang, Zhijie[1];Xin, Xiujuan[1];An, Faliang[1]

机构：[1]East China Univ Sci & Technol, Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Beijing Technol & Business Univ, Key Lab Cosmet, China Natl Light Ind, 33 Fucheng Rd, Beijing 100048, Peoples R China

年份：2021

卷号：19

期号：3

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000633818500001)】；

基金：This work was funded by the National Key R&D Program of China (2018YFC1706206, 2019YFC0312504), and the National Natural Science Foundation of China (41876189, 81703388). This work was also supported by State Key Laboratory of Bioreactor Engineering and the Open Research Fund Program of Institute of regulatory science, Beijing Technology and Business University (CRS2020-02), the Open Research Fund Program of Key Laboratory of Cosmetic (Beijing Technology and Business University), China National Light Industry (KLC-2019-ZD2).

语种：英文

外文关键词：indole diketopiperazine alkaloids; endophytic fungus; Aspergillus sp; antimicrobial

摘要：Six new prenylated indole diketopiperazine alkaloids, asperthrins A-F (1-6), along with eight known analogues (7-14), were isolated from the marine-derived endophytic fungus Aspergillus sp. YJ191021. Their planar structures and absolute configurations were elucidated by HR-ESI-MS, 1D/2D NMR data, and time-dependent density functional theory (TDDFT)/ECD calculation. The isolated compounds were assayed for their inhibition against three agricultural pathogenic fungi, four fish pathogenic bacteria, and two agricultural pathogenic bacteria. Compound 1 exhibited moderate antifungal and antibacterial activities against Vibrio anguillarum, Xanthomonas oryzae pv. Oryzicola, and Rhizoctonia solani with minimal inhibitory concentration (MIC) values of 8, 12.5, and 25 mu g/mL, respectively. Furthermore, 1 displayed notable anti-inflammatory activity with IC50 value of 1.46 +/- 0.21 mu M in Propionibacterium acnes induced human monocyte cell line (THP-1).