文献类型：期刊文献

英文题名：Nickel-catalyzed acylation of vinylpyridine with alkylzincs under 1 atm CO

作者：Huang, Wenyi[1];Wang, Chenglong[1];Zhang, Yetong[1];Qu, Jingping[1];Chen, Yifeng[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2024

卷号：22

期号：12

起止页码：2380

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20241115719953);WOS:【SCI-EXPANDED(收录号:WOS:001177315100001)，CCR-EXPANDED(收录号:WOS:001177315100001)】；

基金：This work was supported by the Key Project of Science and Technology Innovation 2030 (No. 2023ZD0121001, 2023ZD0121002), the National Natural Science Foundation of China (22171079, 22371071, 92356301), the Natural Science Foundation of Shanghai (21ZR1480400), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities. The authors thank the Analysis and Testing Center of East China University of Science and Technology for help with NMR and HRMS analysis.

语种：英文

外文关键词：Atmospheric pressure - Catalysis - Nickel - Pyridine - Synthesis (chemical)

摘要：A nickel-catalyzed acylation of vinylpyridines with CO at atmospheric pressure is reported, allowing for an expedient approach to synthesize beta-acyl pyridine derivatives with high regio- and chemoselectivity. The electron-withdrawing property of pyridine plays pivotal roles in activating the alkenyl group, thereby facilitating this carbonylative process. In addition to vinylpyridines, other alkenylheterocycles such as thiazole and quinoline were also suitable for this method. A nickel-catalyzed acylation of vinylpyridines with CO at atmospheric pressure is reported, allowing for an expedient approach to synthesize beta-acyl pyridine derivatives with high regio- and chemoselectivity.