文献类型：期刊文献

英文题名：Manipulation of pH-Sensitive interactions between podophyllotoxin-chitosan for enhanced controlled drug release

作者：Chen, Chao[1];Yu, Yong[1];Wang, Xiaoli[1];Shi, Ping[1];Wang, Yibing[1];Wang, Ping[1,2]

机构：[1]East China Univ Sci & Technol, Biomed Nanotechnol Ctr, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2017

卷号：95

起止页码：451

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20242616467226);WOS:【SCI-EXPANDED(收录号:WOS:000392903000057)】；

基金：This work was supported by the National Natural Science Foundation of China (21303050 and 31471659), the China Postdoctoral Science Foundation (2015M571511), and the Fundamental Research Funds for the Central Universities (WF1113014 and 222201514327). Authors thank the support from Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM).

语种：英文

外文关键词：Chitosan nanoparticles; Podophyllotoxin; pH-sensitivity; Controlled release; Cancer treatment

摘要：Podophyllotoxin (PPT) offers a broad-spectrum of anticancer activities, but little has been reported for its controlled release. This work shows that by manipulating molecular interactions between PPT and Chitosan, efficient nanoscale capsulation of PPT can be realized. The drug encapsulation efficiency is as high as 52%, with a final particle drug loading in the order of 10% (wt/wt). It further demonstrates that changes in pH can also significantly affect the rate of drug release from the Chitosan nanoparticles. Upon contact with cancer cells, chitosan nanoparticles enable efficient internalization and drug release. In vitro evaluations with HepG-2 and MCF-7 cells indicate that the chitosan nanoparticle carriers can improve drug efficacy in comparison to free PPT, most likely by regulating the intrinsic apoptotic signaling pathway to induce apoptosis. Overall, PPT chitosan nanoparticles promise a safe and efficient drug delivery system for PPT. (C) 2016 Elsevier B.V. All rights reserved.