文献类型：期刊文献

英文题名：Facile synthesis of ROS-responsive biodegradable main chain poly(carbonate-thioether) copolymers

作者：Yan, Bingkun[1];Zhang, Yan[1];Wei, Chao[1];Xu, Yue[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2018

卷号：9

期号：7

起止页码：904

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20180804818612);WOS:【SCI-EXPANDED(收录号:WOS:000424995800013)】；

基金：This work was supported by the Shanghai Natural Science Foundation (17ZR1407100) and 111 Project (B14018).

语种：英文

外文关键词：Functional polymers - Biodegradable polymers - Medical applications - Oxidation - Hydrophilicity - Ring opening polymerization - Drug delivery

摘要：Oxidation-responsive thioether-functional polymers have emerged as potential materials for biomedical applications. Herein, we report the straightforward synthesis of a well-defined biodegradable thioether-containing polycarbonate (mPEG-b-PS) based on the macrocyclic sulfur-substituted carbonate monomer (MS) using an enzyme-catalyzed ring-opening polymerization with the thioether groups situated on the backbone. NMR, FTIR and GPC techniques were employed to confirm the structure of the copolymers. Moreover, the thioether groups endowed the copolymers with rich ROS responsiveness and the oxidation mechanism was clarified according to in situ H-1-NMR, FTIR and TGA data. In addition, the water contact angles testified that the hydrophilicity of the copolymers was greatly improved during the H2O2 triggered oxidation process. The thioether oxidation to polar sulfone and sulfoxide groups enabled us to tailor the copolymer's solubility profile; thus, the size, morphology and transmittance of the nanostructure changed according to the results obtained using DLS, TEM and UV techniques. Furthermore, CCK-8 assays showed that the thioether-containing polycarbonate and their oxidized products were non-toxic up to a tested concentration of 250 mu g mL(-1). Moreover, the mPEG-b-PS had a definite H2O2-triggered drug release behaviour. Therefore, these results highlight a facile synthesis of biodegradable thioether-containing polymers and provide a novel ROS responsive material platform for further cancer therapy and inflammation targeting.