文献类型：期刊文献

英文题名：A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4′,3′-e]pyridine derivatives by a Hantzsch-type reaction

作者：Zhao, Kun[1];Lei, Min[1];Ma, Lei[2];Hu, Lihong[1]

机构：[1]Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：142

期号：11

起止页码：1169

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000297216100012)】；

基金：This work was supported by the Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' (Grants 2009ZX09301-001, 2009ZX09102-022), the National Natural Science Foundation of China (Grants 21002027, 90713046, 30772638 and 30925040), and CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Hantzsch-type reaction; Aldehyde; 3-Methyl-1H-pyrazol-5(4H)-one; Catalyst-free

摘要：A facile and efficient protocol is described for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4',3'-e]pyridine derivatives in good yields by the condensation of 3-methyl-1H-pyrazol-5(4H)-one, aromatic aldehydes, and ammonium acetate under catalyst-free conditions. The advantages of this protocol are operational simplicity, mild reaction conditions, high yields, and little environmental impact.