文献类型：期刊文献

英文题名：Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells

作者：Zhao, Dan[1,2];Han, Hai-Hao[1,2];Zhu, Ling[1,2];Xu, Fang-Zhou[1,2];Ma, Xing-Yu[1,2];Li, Jia[3];James, Tony D.[4,5];Zang, Yi[3];He, Xiao-Peng[1,2];Wang, Chengyun[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[5]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

年份：2021

卷号：4

期号：9

起止页码：7016

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20213910957232);WOS:【ESCI(收录号:WOS:000699828900040)】；

基金：The authors thank the National Natural Science Foundation of China (No. 21788102), the National Science and Technology Major Project of China (No. 2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), and the Fundamental Research Funds for the Central Universities (222201717003) for financial support. T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). H.-H.H. would like to thank the Project funded by China Postdoctoral Science Foundation (No. 2020M681196).

语种：英文

外文关键词：aggregation-induced emission (AIE); photodynamic therapy (PDT); photosensitizer; mitochondria; theranostic probe

摘要：With this research, we have developed two long-wavelength theranostic probes (DCMT and DCMC) with aggregation-induced emission (AIE)-based properties for image-guided photodynamic therapy (PDT) of hepatoma cells. Introduction of a triphenylamine or carbazole group to a dicyanomethylene-4H-pyran dye with long-wavelength fluorescence emission produces the AIE-based probes, which were subsequently modified with triphenyl-phosphonium cation for actively targeting the mitochondria of hepatoma cells. Solution-based experiments show that the probes exhibit a mixed photophysical mechanism of twisted-intramolecular charge transfer and AIE at different aggregation states. The molecular aggregation of the probes also leads to an enhanced ability for oxygen photosensitization, suggesting their potential for PDT of cancer cells. Our subsequent cell-based assays show that the probes localize in the mitochondria of hepatoma cells and the use of light leads to cell death through the intracellular production of reactive oxygen species.