文献类型：期刊文献

英文题名：Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes

作者：Yang, Song[1,2];Li, Quan-Zhe[1,2];Xu, Chen[1,2];Xu, Qin[1,2];Shi, Min[1,2,3,4,5]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China;[4]Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China;[5]Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Ctr Excellence Mol Synth,Chinese Acad Sci, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2018

卷号：9

期号：22

起止页码：5074

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20182405299456);WOS:【SCI-EXPANDED(收录号:WOS:000434693300020)，CCR-EXPANDED(收录号:WOS:000434693300020)】；

基金：We are grateful for the financial support from the National Basic Research Program of China [(973)-2015CB856603], the Strategic Priority Research Program of the Chinese Academy of Sciences (grant no. XDB20000000 and sioczz201808), the National Natural Science Foundation of China (20472096, 21372241, 21572052, 20672127, 21421091, 21372250, 21121062, 21302203, 21772037, 21772226, 20732008 and 21772037), and the Fundamental Research Funds for the Central Universities (222201717003).

语种：英文

外文关键词：Amines - Rhodium compounds

摘要：We reported a highly regio- and enantioselective hydroamination and hydroindolation of keto-vinylidenecyclopropanes via cationic Rh(I) catalysis in this context. The combination of various secondary amines and indoles with keto-vinylidenecyclopropanes afforded the corresponding hydrofunctionalization products in good to excellent yields with outstanding ee values under mild conditions. A new TMM-Rh model complex was proposed, providing an atom economical Rh-pi-allyl precursor at the same time. Moreover, the resulting products could easily be transformed into more complex polyheterocycles upon further synthetic manipulation.