文献类型：期刊文献

英文题名：Muscle Fibrous Porous Microspheres Boost Rotator Cuff Regeneration within a Biomimetic Dynamic Mechanical Niche

作者：Lian, Ruixian[1]; Xu, Junjie[2]; Zhou, Dong[1]; Xiao, Lan[5]; Chen, Qi[1]; Rafique, Muhammad[6]; Ali, Onaza[7]; Bai, Zhishan[4]; Lia, Yulin[3]; Liua, Changsheng[3]

机构：[1] The Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 201306, China; [3] Wenzhou Institute of Shanghai University, Wenzhou Key Laboratory of Tissue Regeneration Medical Materials, Wenzhou, 325000, China; [4] State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, 200237, China; [5] School of Medicine and Dentistry, Griffith University, QLD, 4222, Australia; [6] School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, China; [7] United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250427201)

语种：英文

外文关键词：Biomaterials - Biomechanics - Biomimetic materials - Biomimetics - Composite materials - Tissue regeneration - Topology

摘要：Chronic rotator cuff injuries significantly affect patients both physically and mentally, with current treatments often failing to address the degenerative nature of the condition, leading to a high risk of post-surgery re-tearing. Biomimetic materials are likely to provide new options and concepts for treatment. Herein, we developed a regenerative engineering approach using FDA-approved materials to prepare microspheres with a muscle fibrous porous structures, which are delivered via minimally invasive techniques. Additionally, we designed an in vitro biomechanical stimulation device that mimics muscle movement. Our strategy leverages the "active and passive effects" of these materials to reveal mechanisms of muscle tissue regeneration that benefit degenerative lesions. In vitro studies revealed enhanced vascularization, cell migration, and proliferation; in a model of chronic rotator cuff muscle degeneration, in vivo histological analyses after 16 weeks showed reduced fat accumulation, reversal of muscle atrophy and fibrosis, and improved vascularization and nerve regrowth. The introduction of microspheres mimicking muscle fiber structure accelerated muscle regeneration, confirming the potential of this approach in the treatment of muscle-related injuries. ? 2025, The Authors. All rights reserved.