文献类型：期刊文献

英文题名：Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons

作者：Zheng, Jing[1];Xu, Da-Feng[1];Li, Kui[1];Wang, Hong-Tao[1];Shen, Peng-Cheng[1];Lin, Min[1];Cao, Xiao-Hua[2];Wang, Rui[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]E China Normal Univ, Shanghai Inst Brain Funct Gen, Lab Synapt Plast & Learning Behav, Shanghai 200062, Peoples R China

年份：2011

卷号：4

期号：2

起止页码：162

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000293510100005)】；

基金：We would like to thank Professor Zhi-Qi Xiong for providing some laboratory apparatus and guidance, and also we thank Ting-Jia Lu for her help with the experiments. This work is supported by 111 Project (B07023) and China Postdoctoral Science Foundation (20090460649) to Jing Zheng.

语种：英文

外文关键词：SSRI; dendritic spine density; neuronal development; fluoxetine; fluvoxamine

摘要：Some women in childbearing ages take selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and fluvoxamine for treating psychiatric symptoms. However, these compounds may cause some side effects to their children. It has been identified that early life exposure to SSRIs increased the chance of developing mood disorders and the biological basis is still unclear. Here, we studied the effects of neonatal exposure to SSRIs on neuronal morphology. We used GFP-transgenic mice to investigate the acute and long-lasting effects of early life exposure to SSRIs on dendritic spine density of CA1 neurons. We found that 18-day drug applications of fluoxetine and fluvoxamine significantly reduced spine density of basal dendrites at postnatal day 22 (P22), but only fluvoxamine caused a reduction of spine density of apical dendrites. Interestingly, compared with the control group, the spine densities of basal dendrites after fluoxetine and fluvoxamine exposure and the spine density of apical dendrites after fluoxetine exposure increased in adult mice at the age of P90. We also observed impaired locomotor activity in adult mice after exposure to SSRIs. Our findings demonstrated that neonatal exposure to SSRIs was capable of influencing the morphological plasticity of excitatory synapses. It raised the caution for clinical use of SSRIs.