文献类型：期刊文献

英文题名：Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification

作者：Tian, Zhongzhen[1];Shao, Xusheng[1];Li, Zhong[1];Qian, Xuhong[1];Huang, Qingchun[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, POB 544, Shanghai 200237, Peoples R China

年份：2007

卷号：55

期号：6

起止页码：2288

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000244867300036)】；

语种：英文

外文关键词：nitromethylene; tetrahydropyridine; cis position; QSAR

摘要：To keep the nitro group in the cis position, a series of nitromethylene neonicotinoids containing a tetrahydropyridine ring with exo-ring ether modifications were designed and synthesized. All of the compounds were characterized and confirmed by H-1 NMR, high-resolution mass spectroscopy, elemental analysis, and IR. The bioassay tests showed that some of them exhibited good insecticidal activities against pea aphids. On the basis of 10 nitromethylene derivatives, the quantitative structure-bioactivity relationship (QSAR) was analyzed and established. The results suggested that AlogP98 and Dipole_Mopac might be the important parameters related with biological activities.