文献类型：专利

英文题名：Self-repairing hydrogel of high mechanical property comprises synthesizing chiral monomer, chiral block copolymer and preparing self-repairing hydrogel

作者：ZHANG R;WANG L;CHEN Z;YAO Y;LIU L;HOU X;ZHANG H;LI M;DENG J;ZHU X

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN107141431-A

申请日：2017-05-23

公开日：2017-09-08

语种：英文

收录：DERWENT

摘要：NOVELTY - Self-repairing hydrogel of high mechanical property, is claimed. The hydrogel has regular three-dimensional network structure and aperture is 15-30 mu m. USE - Used as self-repairing hydrogel. ADVANTAGE - The self-repairing hydrogel is prepared using in-situ polymerization and is easy to control. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing hydrogel, comprising (i) synthesizing chiral monomer 5-12 g leucine methyl ester hydrochloride (H-Leu-OMe HCl), 30-100 ml 1x 10-3-5x 10-3 mol/l potassium carbonate (K2CO3) to obtain colorless transparent solution, adjusting the pH to 8-12 using 1-4 mol/l potassium hydroxide solution, placing in ice bath, adding 3-10 ml acryloyl chloride dropwise while stirring, allowing to react for 1-5 hours, controlling pH of the solution, keeping in 8-12 degrees C after the reaction, using 0.5-2 mol/l hydrochloride to adjust pH value of the solution to 1-5 and extracting using 5-40 ml dichloromethane for three times, extracting the obtained solution with anhydrous sodium sulfate, filtering and steaming to obtain final oily monomer and naming as LAC; (ii) synthesizing chiral block copolymer comprises (a) dissolving 5-20 g polyethylene glycol (PEG) 5000 in 20-50 ml anhydrous dichloromethane to obtain colorless transparent solution, placing in ice bath, adding 0.1-1 ml triethylamine, stirring gradually while adding 0.1-3 ml 2-isobutyryl bromine, removing from ice bath after 10-40 minutes, allowing to react in room temperature for 8-20 hours to obtain solution with anhydrous ether to precipitate, filtering and drying to obtain white solid polyethylene glycol-bromine (PEG-Br); (b) taking 1-5 g PEG-Br, 0.1-0.5 ml pentamethyldiethylenetriamine (PMDETA), 0.01-1 g copper chloride, mixing 1-6 g LAC in 5-20 ml dimethylformamide, placing in 125 ml reaction bottle, freezing and vacuum circulating treatment for after three times, filling nitrogen gas and sealing, placing in 50-100 degrees C oil bath, allowing to react for 8-20 hours, cooling to room temperature after finishing reaction, adding 10-80 ml dichloromethane, adding to overbased aluminum oxide column to remove the catalyst, using ether-petroleum mixed solution for precipitating operation, filtering and vacuum drying to obtain white solid PEG-PLAC; (c) dissolving 0.1-1 g PEG-PLAC in 5-20 ml methanol, adding 1-5 ml sodium hydroxide (1-4 mol/l) stirring at room temperature overnight, neutralizing with 1-3 mol/l ammonium sulfate, extracting organic solvent, freeze-drying remaining solution, dissolving solid in methanol, filtering to remove solid salt after polymer precipitating with ether to obtain white solid PEO-PLAA; and (iii) dissolving 0.1-2 g synthesized block copolymer PEO-PLAA in water to prepare 0.01-1 wt.% aqueous solution, taking 0.1-1 ml solution, 0.2-2 ml acrylic acid, 0.3-2 ml water, 0.02-0.3 g photoinitiator and mixing glass mold, subjecting to ultrasonication for 5-40 minutes and irradiating with ultraviolet lamp for 10-120 minutes.