文献类型：期刊文献

英文题名：Preparation and characterization of fibrous chitosan-glued phosphate glass fiber scaffolds for bone regeneration

作者：Zheng, Kai[1];Wu, Zhaoying[2];Wei, Jie[2];Russel, Christian[3];Liang, Wen[4];Boccaccini, Aldo R.[1]

机构：[1]Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany;[2]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]Univ Jena, Otto Schott Inst Mat Res, D-07743 Jena, Germany;[4]E China Univ Sci & Technol, Inst Biomat, Shanghai 200237, Peoples R China

年份：2015

卷号：26

期号：8

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20153401183876);WOS:【SCI-EXPANDED(收录号:WOS:000361312700009)】；

基金：The financial support of National Nature Science Foundation of China (Project for Young Scientists Fund No. 50902048) and Program for Changjiang Scholars and Innovative Research Team in University (IRT0825) was acknowledged. Kai Zheng acknowledges the scholarship from China Scholarship Council (CSC NO.201206740003).

语种：英文

外文关键词：Pore size - Bone - Phosphate minerals - Chitosan - Glues - Gluing - Compressive strength - Glass fibers - Scaffolds (biology) - Bioactive glass

摘要：Phosphate glass fibers (PGF) have emerged as promising building blocks for constructing bone scaffolds. In this study, fibrous scaffolds (PGFS) were fabricated using a facile binding method at room temperature. PGFS exhibited an extracellular matrix-like morphology and were composed of PGF as matrix and chitosan as the natural binding glue. They showed an interconnected porous structure with a porosity of similar to 87 % and pore size of 100-500 mu m. PGFS exhibited the typical compressive stress-strain behaviour of highly porous, low-density, open-cell scaffolds. Their yield stress and modulus were similar to 0.38 and similar to 2.84 MPa, respectively, with the strength being higher than the lower bound of the compressive strength of cancellous bone. PGFS were degradable and the weight loss was about 25 % after immersion in stimulated body fluid (SBF) for 28 days. In addition, the yield stress and the modulus decreased with increasing immersion time in SBF. Apatite formation could be detected on the surface of PGFS within 7 days of immersion in SBF. MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) assay indicated that PGFS were non-cytotoxic against bone marrow stromal cells (bMSCs) after culture for up to 72 h. These results suggest that PGFS could be promising scaffolds for bone regeneration applications.