文献类型：期刊文献

英文题名：Smart Biomaterials for Articular Cartilage Repair and Regeneration

作者：Gu, Zhanghao[1,2];Wang, Jiayi[1,2];Fu, Yu[3];Pan, Hao[1,2];He, Hongyan[1,2,4];Gan, Qi[1,2,4];Liu, Changsheng[1,2,4,5]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Aerosp Engn & Appl Mech, Zhangwu Rd 100, Shanghai 200092, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2023

卷号：33

期号：10

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20230213356448);WOS:【SCI-EXPANDED(收录号:WOS:000907411800001)】；

基金：This work was supported by the Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 32071337), Shanghai Pujiang Program (20PJ1402600) and the 111 Project (B14018). This study was also supported by "the Fundamental Research Funds for the Central Universities".

语种：英文

外文关键词：articular cartilage repair and regeneration; smart biomaterials; smart drug release; smart scaffolds

摘要：Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular cartilage repair and regeneration is recognized as a global issue. However, due to its avascular and nearly acellular characteristic, cartilage tissue regeneration ability is limited to some extent. Despite the availability of various treatment methods, including palliative drugs and surgical regenerative therapy, articular cartilage repair and regeneration still face major challenges due to the lack of appropriate methods and materials. Smart biomaterials can regulate cell behavior and provide excellent tissue repair and regeneration microenvironment, thus inducing articular cartilage repair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli, tailoring materials' structure and function similar to native cartilage or providing physiochemical and physical signaling factors. Herein, smart biomaterials, recently applied in articular cartilage repair and regeneration, are elaborated from two aspects: smart drug release system and smart scaffolds. Furthermore, articular cartilage and its defects and advanced manufacturing techniques of smart biomaterials are discussed in brief. Finally, perspectives for smart biomaterials used in articular cartilage repair and regeneration are presented and the clinical translation of smart biomaterials is emphasized.