文献类型：期刊文献

英文题名：Development of the VARICOL Process for the Resolution of Racemic Menthol

作者：Sun, Linhe[1,2];Yang, Ying[1,2];Yu, Jianguo[1,2]

机构：[1]East China Univ Sci & Technol, Natl Engn Res Ctr Integrated Utilizat Salt Lake Re, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Resources Proc Engn, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2026

卷号：13

期号：3

外文期刊名：SEPARATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001726185300001)】；

基金：This work was supported by the National Key R&D Program of China [grant number 2023YFB4104000]. This work was also supported by the Key Research and Development Program of Jiang-xi Province [20223BBG74008] and the ECUST-Jinghao Salt Chemical Carbon and Calcium Cycles Joint Research Centre.

语种：英文

外文关键词：l-menthol; chiral separation; simulated moving bed; VARICOL; mathematical model

摘要：This paper reports the chiral separation of menthol enantiomers using the VARICOL process to improve productivity. Amylose 3,5-dimethylphenylcarbamate coated on silica gel was employed as the chiral stationary phase, and n-hexane/2-propanol (95/5, v/v) was used as the eluent. To design and optimize the VARICOL process, a linear driving-force model was developed to predict the separation performance. Separation regions of the conventional simulated moving bed (SMB) and VARICOL processes were evaluated and compared. It was found that, under an outlet purity requirement of 95.0%, the five-column VARICOL process has a separation region comparable to that of the six-column conventional SMB process. As an illustrative example, a five-column VARICOL unit and a six-column conventional SMB unit, both operating under the same conditions, were employed to resolve the menthol racemate. Purities for both the extract and raffinate were above 95.0%, and a productivity of 0.400 gracemate/(LCSP center dot min) and a solvent consumption of 0.355 L/gracemate were achieved in the VARICOL process. Productivity increased by 20% while solvent consumption maintained relative to the conventional SMB process, though product purities decreased slightly.