文献类型：期刊文献

英文题名：Advances in the construction of diverse SuFEx linkers

作者：Zeng, Daming[1,2];Deng, Wei-Ping[1];Jiang, Xuefeng[2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

年份：2023

卷号：10

期号：6

外文期刊名：NATIONAL SCIENCE REVIEW

收录：;EI(收录号：20233114463928);WOS:【SCI-EXPANDED(收录号:WOS:001025975600001)】；

基金：This work was supported by the National Natural Science Foundation of China (22125103 and 21971065), the Science and Technology Commission of Shanghai Municipality (22JC1401000, 20XD1421500 and 20JC1416800) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：SuFEx; SuFEx linker; S-VI-F bond; synthetic strategy

摘要：Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient reactivity of the S-VI-F bond, SuFEx has found widespread applications in organic synthesis, materials science, chemical biology and drug discovery. A diverse collection of SuFEx linkers has emerged, involving gaseous SO2F2 and SOF4 hubs; SOF4-derived iminosulfur oxydifluorides; O-, N- and C-attached sulfonyl fluorides and sulfonimidoyl fluorides; and novel sulfondiimidoyl fluorides. This review summarizes the progress of these SuFEx connectors, with an emphasis on analysing the advantages and disadvantages of synthetic strategies of these connectors based on the SuFEx concept, and it is expected to be beneficial to researchers to rapidly and correctly understand this field, thus inspiring further development in SuFEx chemistry. SuFEx linkers are of great importance in the sulfur-fluoride cleavage and linkage chemistry, and their development and synthesis have been discussed in this review.