文献类型：期刊文献

英文题名：An effective peptide cargo carrier for the delivery of cisplatin in ovarian cancer cells

作者：Lai, Yanhua[1,2];Zhao, Ping[1,2];Zhang, Zhan[3];Li, Bai[3];Wu, Junchen[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Changhai Hosp, Changhai Rd 168, Shanghai, Peoples R China

年份：2017

卷号：143

起止页码：342

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20171803635441);WOS:【SCI-EXPANDED(收录号:WOS:000403122900042)】；

基金：We thank the National Basic Research 973 Program (2013CB733700), NSFC/China (91529101 and 21572057) for financial support.

语种：英文

外文关键词：Peptide cargo carrier; Targeted delivery; Cisplatin; Ovarian cancer; Disassembly

摘要：The self-assembled peptide cargo carrier with the ability of probe offered an effective strategy to deliver and track the anticancer drug, cisplatin (DDP) in ovarian cancer cells. This simple peptide system containing a pyrene fluorogen and arginine-glycine-aspartic acid (RGD) sequence could be utilized to release DDP in situ by the specific recognition between an RGD motif and alpha(v)beta(3) integrin that was over-expressed on ovarian cancer cells. Importantly, we found that the disassembly-triggered peptide nanofibers, PA1, could effectively combine with DDP and release DDP in the cytoplasm with the pyrene fluorescence restoring. Moreover, the peptide cargo carrier efficiently penetrated tumour cells for enhancing therapeutic efficacy. Our system could open the door for the delivery of anticancer drug in cancer-related therapy. (C) 2017 Elsevier Ltd. All rights reserved.