文献类型：期刊文献

英文题名：A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography

作者：Zhang, Sainan[1];Zhang, Feifang[1];Yang, Bingcheng[1];Liang, Xinmiao[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2019

卷号：30

期号：2

起止页码：470

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000458344600058)】；

基金：The work was financially supported by the National Natural Science Foundation of China (Nos. 21477037, 21322502) and the Outstanding Young Talent Cultivation Fund of East China University of Science and Technology.

语种：英文

外文关键词：Mixed-mode; Stationary phase; Reversed phase liquid chromatography; Hydrophilic interaction liquid chromatography; Ion exchange; Drug molecules

摘要：A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines (N,N-dimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode. The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.