文献类型：期刊文献

中文题名：Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin

英文题名：Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by a-cyclodextrin

作者：Lei Huang[1];Jiaojiao Chen[1];Muye He[1];Xinyu Hou[1];Yiben Lu[1];Kaiyan Lou[1,2];Feng Gao[3,1,2]

机构：[1]Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology;[2]Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology;[3]Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology

年份：2019

卷号：30

期号：1

起止页码：163

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：supported by Science and Technology Commission of Shanghai Municipality (Nos. 17ZR1406600, 10DZ2220500, 11DZ2260600);National Natural Science Foundation of China (No.21577037)

语种：英文

中文关键词：a-Cyclodextrin;mPEG Grafted chitosan;Self-assembly;Nanoparticle;Drug delivery

外文关键词：α-Cyclodextrin;mPEG;Grafted;chitosan;Self-assembly;Nanoparticle;Drug;delivery

摘要：This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin(α-CD). The effect of α-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol(mPEG) grafted chitosan(CS) was studied. The results showed that the mPEG grafted chitosan(mPEG-g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of α-CD to mPEG, as characterized by atomic force microscopy(AFM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of α-CD. The correlation between zeta potential and particle size of α-CD/mPEG-g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-g-CS was proposed.
This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin(a-CD). The effect of a-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol(mPEG) grafted chitosan(CS) was studied. The results showed that the mPEG grafted chitosan(mPEG-[9_TD$IF]g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of a-CD to mPEG, as characterized by atomic force microscopy(AFM), transmission electron microscopy(TEM), and X-ray diffraction(XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of a-CD. The correlation between zeta potential and particle size of a-CD/mPEG-[9_TD$IF]g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-[9_TD$IF]g-CS was proposed.